Hospital use of antimicrobial agents: cefminox Features Breakthrough - cefminox, bulk drugs - the ph

Cephalosporin Antibiotic anti-infective drugs in our country a strong force, due to broad spectrum antibacterial, antimicrobial activity, and allergic reactions characterized by small, some species also showed -lactamases on the merits and on the aerobic stability and mixed infection of anaerobic activity, so at this stage cephalosporins has become a market leader in anti-infective species.

In 2006 ~ 2008 3 years, the domestic focus of the city hospital anti-infective market in the sample, the drug cephalosporins accounts for more than 45% share, a powerful antibiotic variety. Focus on new drugs to promote academic Education Promotion and clinical needs, driven by the market cephalosporins speed since 2002, has experienced 3 consecutive years of rapid growth, two years of retail prices and market conduct regulation consolidation adjustment period last year, hitting record history high. According to statistics of Chinese Pharmaceutical Association, 2008, samples of the 22 major cities in the amount of hospital cephalosporin drugs has reached 7.022 billion yuan, accounting for the total amount of the body with anti-infectives market share of 53.67 percent.

"Cephalosporin" Spring and Autumn Period
Present, the sample hospitals and clinical use of cephalosporin compound over the 40 drugs, the top 200 drugs are 23 varieties of cephalosporin. Many small manufacturers cephalosporins species sought after in many years, gradually grow, cefepime, Cefamandole, cefminox, cefpiramide, cefixime, Ceftezole, ceftizoxime, cefoxitin, ceftriaxone other sort of drug in the market continuously turns forward, thus creating a "cephalosporins Spring and Autumn Period" situation. This also shows that even with good varieties with good market Marketing Means to promote the new drug product bigger and stronger, if there is no effective academic education, promotion and publicity and Sell Means to really big product is very difficult.

Is well known that cephalosporins have been developed to the fourth generation, first generation cephalosporin is the early 60s of the 20th century began listing of foreign species, and the prevalence of certain liver and kidney toxicity. Second-generation cephalosporin antibacterial spectrum than the first generation has expanded the clinical application of second-generation cephalosporins are the main varieties of cefuroxime and for security and so on, its vice toxicity smaller than the first-generation cephalosporins; s The antibacterial spectrum of third generation cephalosporins than the second generation there are expanded into the mainstream of the current domestic market, while the fourth generation cephalosporins against -lactamase has a good stability. At present, the sample hospitals leading position in the market is still the second and third generation of varieties, presents "olive" posture, which originally belongs to the variety of small cephalosporins have accounted for a quarter of the market share.

Features open market Market data shows that rapid growth in drugs, fierce competition in today's abnormal, has certain characteristics, varieties can be in the market have a foothold. Cefminox (Cefminox) to cephamycin derivatives, the antibacterial spectrum of gram-negative bacteria on the role of strength than the second generation cephalosporins, while the role of gram-positive bacteria stronger than the third-generation cephalosporins, but also weaker than the second generation cephalosporins. And there are strong anti Cefminox -lactamase performance, can inhibit cell wall biosynthesis, combined with the polysaccharide peptide, peptide inhibition of polysaccharide and lipoproteins and the promotion of lysozyme, which accounts for the clinical use on a certain advantage.

Cephamycin and cephalosporin only seven different substituents, as cephamycin 7-methoxy cephalosporin 7 is a hydrogen-based. Thus, cephamycin antibiotics enhanced role of anaerobic bacteria, Gram-negative bacteria Cefminox addition to a stronger role, while also effective against anaerobic bacteria, is anti-bacterial, anaerobic mixed Infection by the use of drugs, the characteristics of the antimicrobial spectrum under the influence of cefminox samples in the past two years has been in hospital administration in the list of the leading varieties, wide as the tonsils, respiratory tract, urinary tract, biliary tract, abdominal cavity, uterus and other parts infections. Sample hospitals in 2008 before the list of 200 drugs ranked 19.

Cefminox first by the Japanese Meiji Seika developed market, and patented in Japan.



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